Which two enzymes are primarily increased in necrotic liver disease?

In necrotic liver disease, the primary enzymes that typically exhibit increased levels are alanine aminotransferase (ALT) and aspartate aminotransferase (AST). These enzymes are released into the bloodstream when liver cells become damaged or die, which is characteristic of necrosis. Their elevation is an indicator of liver injury and is often used to assess the extent of liver damage.

ALT is more specific to the liver, while AST can be found in other tissues, including the heart and muscles. However, in the context of liver disease, the ratio of these enzymes can provide valuable information regarding the specific type of liver pathology present.

The alternative choices presented do not accurately represent the enzymes primarily associated with liver necrosis. Alkaline phosphatase and creatine kinase are more relevant to bile duct obstruction and muscle damage, respectively. Alcohol dehydrogenase primarily relates to alcohol metabolism rather than direct liver necrosis. Amylase and lipase are enzymes associated with pancreatic function and are indicative of pancreatic disease, not liver necrosis.