Which lipoprotein fraction carries most of the endogenous triglycerides?

The fraction that carries most of the endogenous triglycerides is very low-density lipoprotein (VLDL). VLDL is synthesized in the liver and is primarily responsible for transporting triglycerides from the liver to peripheral tissues. As VLDL circulates in the bloodstream, it delivers triglycerides to cells, where they can be utilized for energy or stored.

While chylomicrons also transport triglycerides, they predominantly carry dietary triglycerides (exogenous triglycerides) absorbed from the intestine rather than those produced endogenously by the liver. High-density lipoprotein (HDL) primarily functions in reverse cholesterol transport, moving cholesterol from tissues back to the liver, and low-density lipoprotein (LDL) is mainly involved in carrying cholesterol from the liver to peripheral tissues, rather than triglycerides. Thus, VLDL stands out as the main lipoprotein fraction for the transport of endogenous triglycerides.