Which apoprotein is inversely related to the risk of coronary heart disease?

Apoprotein A-1 plays a crucial role in lipid metabolism and is a major component of high-density lipoprotein (HDL), commonly referred to as "good cholesterol." Its main function is to facilitate the reverse transport of cholesterol from peripheral tissues back to the liver for excretion. Elevated levels of Apoprotein A-1 are associated with a reduced risk of coronary heart disease (CHD), as higher HDL levels correlate with a lower incidence of cardiovascular events.

In contrast, Apoprotein B-100 is associated with low-density lipoproteins (LDL), which are linked to an increased risk of CHD due to their role in cholesterol transport that can lead to plaque buildup in arteries. Apoprotein C-III is also associated with triglyceride-rich lipoproteins and can promote atherogenic effects, which means it may contribute to heart disease risk rather than reduce it. Apoprotein E, while important in lipoprotein metabolism, has mixed associations and is not consistently related inversely to coronary heart disease risk in the same way that Apoprotein A-1 is. It is clear that the protective effect on cardiovascular health is specifically attributed to Apoprotein A-1 due to its relationship with HDL cholesterol levels.