Where is ALP primarily derived from in non-pregnant normal adults?

Alkaline phosphatase (ALP) is an enzyme found throughout the body, but in non-pregnant normal adults, it is primarily derived from the liver and bone. In the liver, ALP is involved in various physiological processes, including the metabolism of phosphates, and its levels can indicate liver function or biliary obstruction when elevated. In bone, ALP is produced by osteoblasts and is crucial for bone mineralization and turnover, which is why the enzyme is often measured in conditions related to bone metabolism.

The specific relationship between ALP levels and these two sources makes the liver and bone the correct answer, as they are the predominant tissues contributing to elevated serum ALP in normal physiological states. Understanding this can also help in clinical diagnosis, as different diseases affecting the liver or bone can lead to variations in ALP concentration, guiding further investigation into a patient's condition.