What is the order of mobility of lipoproteins electrophoresed at pH 8.6?

The order of mobility of lipoproteins when subjected to electrophoresis at pH 8.6 is primarily influenced by their size, density, and surface charge. At this pH, the proteins within the lipoproteins acquire negative charges that affect their migration in an electric field.

Chylomicrons are the largest and least dense lipoproteins, making them the slowest to migrate. They have the lowest electrophoretic mobility of the lipoprotein classes due to their size, which results in less interaction with the gel matrix used in electrophoresis.

In contrast, the beta lipoproteins (low-density lipoproteins, LDLs) are smaller and denser than chylomicrons and therefore move more quickly in the electric field. Pre-beta lipoproteins (very low-density lipoproteins, VLDLs) are even smaller and less dense than beta lipoproteins, allowing them to migrate faster due to their size and charge.

Alpha lipoproteins (high-density lipoproteins, HDLs) are smaller than beta and pre-beta lipoproteins and also carry a net positive charge at pH 8.6, which results in a greater speed of migration in comparison to the others.

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