What is the normal kappa/lambda ratio for individuals with normal kidney function?

The normal kappa/lambda ratio for individuals with normal kidney function typically falls within the range of 0.26 to 1.65. This ratio is important in the context of evaluating monoclonal gammopathies, as it helps in identifying abnormalities associated with certain diseases, such as multiple myeloma or other plasma cell disorders.

In healthy individuals, the plasma cells produce immunoglobulins that include both kappa and lambda light chains. These two types of light chains should be present in balanced proportions under normal circumstances. The kappa/lambda ratio ideally indicates that the production of these light chains is well-regulated, reflecting the health of the individual's immune system.

Values outside of this range might suggest an imbalance that could point to pathological conditions or disorders. Therefore, the established normal range provides a critical reference for clinical assessments.