What is Paget's Disease of bone characterized by?

Paget's Disease of bone is primarily characterized by cyclic episodes of bone degeneration and regeneration. This condition involves an abnormal process of bone remodeling, where the normal cycle of bone resorption and formation is disrupted. In Paget's disease, there is an initial phase of excessive bone resorption followed by a phase of excessive bone formation. This results in bones that are larger but structurally abnormal and weaker, leading to various complications such as deformities and an increased risk for fractures.

The nature of the disease leads to periods where bone is actively being remodeled, which can cause pain and lead to complications. As bone is continuously being broken down and reformed, the affected areas can become disorganized, contributing to the clinical manifestations associated with the disorder.

While the condition can lead to a higher likelihood of bone complications, such as fractures or bone deformities, the defining hallmark is indeed this cycle of degeneration and regeneration. This distinguishes Paget's disease from other conditions that might also involve changes in bone density or structure but do not specifically present with these cyclical phases.