What is a significant manifestation of Tangier's disease?

Tangier's disease is characterized by a severe reduction in the amount of high-density lipoprotein (H.D.L.) in the bloodstream. This condition is associated with a genetic mutation that affects the transport of cholesterol and lipids in the body, particularly involving the removal of excess cholesterol from tissues and the transport to the liver for excretion.

Individuals with Tangier's disease exhibit very low or undetectable levels of H.D.L., which is critical for cholesterol metabolism and cardiovascular health. H.D.L. is often referred to as "good cholesterol" because it helps remove harmful excess cholesterol from arteries. The significant reduction in H.D.L. levels leads to a higher risk for cardiovascular diseases.

The other options are associated with different lipid metabolism disorders. For example, high levels of triglycerides are seen in various conditions but are not specifically indicative of Tangier's disease. The accumulation of chylomicrons occurs in disorders affecting lipid absorption or metabolism but is unrelated to the HDL deficiency seen in Tangier's. Similarly, high levels of very-low-density lipoprotein (V.L.D.L.) might indicate other metabolic issues and are not directly connected to Tangier's disease as a primary feature.