In newborns, untreated high bilirubin levels can lead to kernicterus, a serious complication characterized by the deposition of bilirubin in the brain tissue. This condition can result in permanent neurological damage, including motor dysfunction, hearing loss, and cognitive impairments. High levels of bilirubin indicate significant jaundice, which requires careful monitoring and potentially treatment to prevent the bilirubin from crossing the blood-brain barrier and causing these adverse effects.
Kernicterus occurs particularly in cases where hyperbilirubinemia is not managed effectively, especially within the first week of life when newborns are at the highest risk. Effective screening and timely intervention, such as phototherapy or exchange transfusions, are crucial to prevent the escalation of bilirubin levels and subsequent neurological complications. The potential consequences of kernicterus underscore the importance of recognizing and treating high bilirubin levels promptly in neonates.