When evaluating for monoclonal gammopathy, it is indeed important to test both serum and urine. This is because monoclonal gammopathy can manifest through the production of an abnormal protein known as a monoclonal immunoglobulin or M-protein, which can be detected in both serum and urine samples.
Testing serum helps to identify the presence of the monoclonal immunoglobulin in the bloodstream, while urine testing is crucial for detecting light chains of immunoglobulins, known as Bence Jones proteins, which are often excreted in urine by certain plasma cell disorders like multiple myeloma. The combination of these tests provides a comprehensive overview and accurate diagnosis of the condition.
Therefore, for a thorough assessment of monoclonal gammopathy, it is essential to analyze both serum and urine samples, affirming that the statement is true.