Other than pancreatitis, in which condition can lipase be increased?

Lipase is an enzyme primarily produced by the pancreas that plays a crucial role in the digestion of fats. While most commonly associated with pancreatitis, lipase can also be elevated in other conditions, particularly in situations where there is pancreatic damage or dysfunction.

Peptic ulcers, which are sores that develop on the lining of the stomach or the first part of the small intestine, can cause irritation and inflammation that may affect nearby structures, including the pancreas. In cases of complicated ulcers or when there is a concern of associated conditions such as perforation or gastritis, the pancreas can become reactive or stressed, leading to the release of lipase into the bloodstream.

Conditions like hypertension, gastroesophageal reflux, and allergic reactions do not have a direct association with increased lipase levels. Hypertension primarily affects the cardiovascular system, gastroesophageal reflux is related to esophageal irritation and does not typically involve pancreatic enzyme changes, and allergic reactions usually result in histamine-mediated responses rather than pancreatic enzyme alterations. Therefore, among these options, peptic ulcers are the most pertinent condition where lipase levels can rise outside of pancreatitis.