Which symptom is commonly associated with Gaucher's Disease?

In Gaucher's Disease, fatigue is a commonly reported symptom. This is largely due to the body’s inability to break down certain types of fats, leading to the accumulation of glucocerebrosides in various organs, particularly the spleen and liver, which can impair their function. As these organs become enlarged, they may cause inflammation and discomfort, contributing to a general sense of tiredness and lethargy in affected individuals. Additionally, the body's energy levels can be negatively impacted by the disease's progression and its effects on the hematologic system, often leading to anemia, which is another factor contributing to fatigue.

Other options, while they may relate to various health conditions, do not typically characterize Gaucher's Disease. Increased appetite and weight gain are not associated symptoms, as this condition tends to lead to complications that could result in nutritional deficiencies rather than excessive consumption or accumulation of weight. Vision impairment is also not a common symptom in Gaucher's Disease, as the disease primarily affects the spleen, liver, and bone marrow rather than the eyes directly. Thus, fatigue stands out as a significant and recognizable symptom of this condition.