Which hemoglobins migrate with hemoglobin S at pH 8.6?

Hemoglobins that migrate with hemoglobin S at pH 8.6 are typically those that exhibit similar electric charges and are therefore influenced similarly under the conditions of electrophoresis. In this case, hemoglobin G, hemoglobin D Punjab, and hemoglobin O Arab all have properties that cause them to co-migrate with hemoglobin S during electrophoresis at this pH level.

Hemoglobin S, which is associated with sickle cell disease, has a specific charge due to its amino acid composition. Hemoglobin G, D Punjab, and O Arab share structural characteristics that lead to comparable charges, allowing them to migrate at the same rate as hemoglobin S when subjected to an electric field.

The other options contain hemoglobins that do not exhibit this behavior under electrophoresis at pH 8.6, generally because they possess differing charges or structural variations that cause them to migrate differently. This is an important concept for understanding the behavior of various hemoglobins in the context of diagnosing and differentiating hemoglobinopathies.