When GGT is elevated more than ALP, what condition is suggested?

When gamma-glutamyl transferase (GGT) levels are elevated significantly more than alkaline phosphatase (ALP), this pattern is indicative of a condition primarily affecting the liver, such as hepatocellular injury rather than cholestasis (which tends to elevate ALP).

In the context of obstructive jaundice, both GGT and ALP can be elevated due to the obstruction of bile flow, but GGT tends to rise disproportionately more than ALP in cases of liver involvement. This occurs because GGT is produced in response to bile duct obstruction and liver stress, making it a more sensitive marker for hepatic dysfunction.

In conditions like hepatitis, while GGT can also be elevated, the increase is typically not as marked compared to cases of obstructive processes where bile is backing up due to a blockage. Other conditions listed, such as liver cirrhosis and pancreatitis, have different patterns of enzyme elevation that do not support the scenario of GGT being higher than ALP in a pronounced manner. Therefore, the context of GGT being elevated more than ALP suggests an issue related to obstructive jaundice rather than other hepatobiliary or pancreatic conditions.