What does high resolution electrophoresis (HRE) utilize to achieve results?

High resolution electrophoresis (HRE) utilizes high voltage to achieve results. The application of high voltage is crucial as it enhances the separation of molecules, such as proteins or nucleic acids, based on size and charge. Under high voltage, the electric field drives the charged particles through the gel or medium more quickly, allowing for increased resolution and better separation of closely positioned bands. This method is particularly useful in applications requiring precise analysis, such as in diagnostic laboratories for protein or genetic studies, where distinguishing between similar molecules is essential.

Using a standard or low voltage would not provide the necessary force to effectively separate the components of a sample with the required level of resolution. Additionally, while variable voltage can be employed in some techniques, high resolution electrophoresis specifically relies on consistently applying high voltage to maximize the resolution of the resulting bands.