What are the main proteins found in the gamma region during electrophoresis?

The gamma region during electrophoresis primarily contains immunoglobulins, which are essential proteins involved in the immune response. Immunoglobulins, commonly known as antibodies, are produced by plasma cells and are crucial for identifying and neutralizing foreign objects like bacteria and viruses. In serum protein electrophoresis, the gamma globulin region reflects the presence of these immunoglobulins, which can provide insight into immune status and various conditions, including infections, autoimmune diseases, and certain malignancies.

While transferrin and beta lipoprotein are found in other regions (the beta region) and albumin and alpha-2 macroglobulin are primarily in the albumin and alpha regions respectively, they do not constitute the main components of the gamma region. Similarly, fibrinogen and haptoglobin, which are involved in blood coagulation and binding hemoglobin, are not found in the gamma region. The specificity of the gamma region for immunoglobulins makes it a key area for evaluating serum proteins related to immune function.